This Special Issue presents a collection of important U.S. federal antitrust merger remedies since 2000. For anyone trying to understand the U.S. approach to merger remedies, the guidance documents issued by the U.S. federal antitrust enforcement agencies, the Antitrust Division of the United States Department of Justice (“DOJ”) and the Federal Trade Commission (“FTC”) (each, an “Agency,” or collectively, the “Agencies”), are the right starting point. The Agencies, however, have recently called their own prior policies into question. New developments suggest that the Agencies may be less likely to accept remedies or will press for more robust protections. Therefore, it is important to actively monitor new developments in this dynamic environment.